L-Alanyl-Glutamine dipeptide pretreatment attenuates ischemia-reperfusion injury in rat testis
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منابع مشابه
Dimethylsulfoxide attenuates ischemia-reperfusion injury in rat testis.
PURPOSE To evaluate the protective role of dimethylsulfoxide (DMSO) in a rat model of testis ischemia/reperfusion (I/R). METHODS Twenty-four male Wistar rats were randomized in two equal groups. Control rats (G-1) received saline 2.0 ml intraperitoneally (ip) 21, 9 and 1 h before torsion. Experimental rats (G-2) received ip injections of 3% aqueous solution of DMSO, 0.1ml/10g body weight. Sal...
متن کاملPreconditioning with L-alanyl-glutamine reduces hepatic ischemia-reperfusion injury in rats.
PURPOSE To evaluate the effects of pre-conditioning with L-alanyl-glutamine (L-Ala-Gln) in rats subjected to total hepatic ischemia. METHODS Thirty Wistar rats, average weight 300g, were randomly assigned to 3 groups (n=10): G-1--saline, G-2--L-Ala-Gln, G-3--control (Sham). G-1 and G-3 groups were treated with saline 2.0 ml or L-Ala-Gln (0.75mg/Kg) intraperitoneally (ip) respectively, 2 hours...
متن کاملPretreatment of parecoxib attenuates hepatic ischemia/reperfusion injury in rats
BACKGROUND Previous studies showed that cyclooxygenase(COX) was involved in ischemia/reperfusion (I/R) injuries. Parecoxib, a selective inhibitor for COX -2, has been shown to have protective properties in reducing I/R injury in the heart, kidney and brain. The aim of this study was to investigate the effects of parecoxib on hepatic I/R and to explore the underlying mechanisms. METHODS Fifty-...
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Sulodexide is a potent antithrombin agent, however, whether it has beneficial effects on renal ischemia-reperfusion injury (IRI) remains unknown. In the present study, we assessed the therapeutic effects of sulodexide in renal IRI and tried to investigate the potential mechanism. One dose of sulodexide was injected intravenously in Sprague-Dawley rats 30 min before bilateral kidney ischemia for...
متن کاملPretreatment of sildenafil attenuates ischemia-reperfusion renal injury in rats.
Sildenafil was the first selective inhibitor of phosphodiesterase-5 (PDE5) to be widely used for treating erectile dysfunction. Many recent studies have investigated the cardioprotective role of sildenafil in animal models. We evaluated the protective effects of sildenafil in experimental renal ischemia-reperfusion (IR) injury in two studies. In study 1, male Sprague-Dawley rats were divided in...
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ژورنال
عنوان ژورنال: Acta Cirurgica Brasileira
سال: 2011
ISSN: 0102-8650
DOI: 10.1590/s0102-86502011000700005